2. Signaling Pathways
  3. GPCR/G Protein
  4. Adenosine Receptor

Adenosine Receptor

P1 receptor

Adenosine Receptor

Related Products

PDF 1.74 MB

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Isoform Specific Products:

Adenosine Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-146478
    A1/A3 AR antagonist 1
    		Antagonist
    A1/A3 AR antagonist 1 (compound 10) is a potent adenosine 1 (A1) and adenosine 3 (A3) receptor dual antagonist with Kis of 36.7 nM, 25.4 nM and 1.47 nM for human A1, human A3 and rat A1, respectively. A1/A3 AR antagonist 1 can be used for researching kidney failure, inflammatory pulmonary diseases, and Alzheimer’s disease.
    A1/A3 AR antagonist 1
  • HY-110303
    Xanthine amine congener dihydrochloride
    		Antagonist
    Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2 receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model.
    Xanthine amine congener dihydrochloride
  • HY-N0092S1
    Inosine-13C
    		Agonist
    Inosine-13C is the 13C labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.
    Inosine-<sup>13</sup>C
  • HY-A0168S
    Regadenoson-d3
    		Agonist
    Regadenoson-d3 is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with Kis of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents[1][2][3].
    Regadenoson-d<sub>3</sub>
  • HY-A0181S5
    Adenosine monophosphate-15N5,d12 dilithium
    		Agonist
    Adenosine monophosphate-15N5,d12 (AMP-15N5,d12) dilithium is deuterium and 15N labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
    Adenosine monophosphate-<sup>15</sup>N<sub>5</sub>,d<sub>12</sub> dilithium
  • HY-116042
    FSCPX
    		Antagonist 99.72%
    FSCPX is a potent and selective irreversible antagonist of A1 adenosine receptor (A1AR), with low nanomolar potency for binding to the A1AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium.
    FSCPX
  • HY-141865
    Adenosine receptor antagonist 1
    		Antagonist
    Adenosine receptor antagonist 1 is a A2aR-selective antagonist with an IC50 of 0.29 nM and displays 14-fold more selective for A2aR than A2bR.
    Adenosine receptor antagonist 1
  • HY-105093
    N 0861
    N-0861 is a novel selective A1 adenosine receptor antagonist. In studies, it has been shown to be able to inhibit the negative conduction effects (prolonged AH interval) and chest pain caused by adenosine, while having no significant effect on the increase in coronary blood flow velocity caused by adenosine. This indicates that N-0861 has the property of selectively inhibiting A1 adenosine receptors.
    N 0861
  • HY-120487
    VUF8507
    		Modulator
    VUF8507 is an allosteric modulator for adenosine A3 receptor with a Ki of 204 nM.
    VUF8507
  • HY-101300R
    Cirazoline hydrochloride (Standard)
    		Agonist
    Cirazoline (hydrochloride) (Standard) is the analytical standard of Cirazoline (hydrochloride). This product is intended for research and analytical applications. Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM).
    Cirazoline hydrochloride (Standard)
  • HY-W777125
    2-Chloro-3-deazaadenosine
    		Agonist
    2-Chloro-3-deazaadenosine is agonists for adenosine receptor, with Kis of 0.3, 0.08, 25.5 and 1.9 μM, for A1, A2A, A2B, and A3 receptors, respectively.
    2-Chloro-3-deazaadenosine
  • HY-103183R
    CV1808 (Standard)
    		Agonist
    CV1808 (Standard) is the analytical standard of CV1808. This product is intended for research and analytical applications. CV1808?(2-Phenylaminoadenosine) is a non-selective A2?adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively.
    CV1808 (Standard)
  • HY-117184
    MSX-2
    		Antagonist
    MSX-2 is A2A adenosine receptor antagonist, with Ki of 5 nM in human that plays an important role in Parkinson's disease.
    MSX-2
  • HY-123196
    CVT-2759
    		Inhibitor
    CVT-2759 is a potent inhibitor of A1-ADOR, with the IC50 values of 0.18 μM and 9.5 μM to reduce the binding of [3H]CPX in the absence and presence of 1 mM GTP. CVT-2759 plays an important role in slowing AV nodal conduction and thereby ventricular rate without causing AV block, bradycardia, atrial arrhythmias, or vasodilation.
    CVT-2759
  • HY-118444
    (Rac)-WRC-0571
    		Antagonist
    (Rac)-WRC-0571 is a highly potent, orally active and selective, non-xanthine antagonist of A1 adenosine receptors. (Rac)-WRC-0571 inhibits [3H]-N6-cyclohexyladenosine (CHA) binding to guinea pig A1-receptors with a Ki value of 1.1 nM.
    (Rac)-WRC-0571
  • HY-119191
    KF26777 free base
    		Antagonist
    KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an Ki value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma.
    KF26777 free base
  • HY-A0168R
    Regadenoson (Standard)
    		Agonist
    Regadenoson (Standard) is the analytical standard of Regadenoson. This product is intended for research and analytical applications. Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS.
    Regadenoson (Standard)
  • HY-134367
    Ap2A disodium
    Ap2A (disodium) is a symmetrical dinucleoside polyphosphate. Ap2A (disodium) can promote the growth of vascular smooth muscle cells.
    Ap2A disodium
  • HY-14851
    MRE 0094
    		Agonist
    MRE 0094 (Sonedenoson) is a selective activator for adenosine receptor A2A, with a Ki of 490 nM. MRE 0094 exhibits anti-platelet and anti-inflammatory activities.
    MRE 0094
  • HY-124259
    I-AB-MECA
    		Ligand
    I-AB-MECA is an important radioligand for the study of A3 adenosine receptors (A3AR).
    I-AB-MECA
Cat. No. Product Name / Synonyms Application Reactivity
Adenosine Receptor Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.